The construction of both the 250 and 270 grain 375s are similar. The primary benefit of the 250 is to be able to be driven faster for a flatter trajectory. It will work on deer, but that’s a little overkill. It is great on hogs and its primary use is for elk. If moose were on the agenda, move up to the 270 or 300 grain. The same goes for big bear. This is not an African bullet.